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Dorogyne: composition, use, price and effective use

What is Dorogyne? What is Dorogyne used for? What should be noted about possible side effects while taking the drug? Let's take a closer look at SignsSymptomsList about Dorogyne in the article analyzed below!

Active ingredients : Spiramycin, Metronidazol.
Drugs with similar ingredients : Naphacogyl, Arme-Rogyl, Vinphazin, ..

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What is Dorogyne? Ingredients in the drug formula

Dorogyne: composition, use, price and effective use

Dorogyne pill box and capsule

Dorogyne is a combination drug between Spiramycin - Macrolide antibiotic and Metronidazol - Nitro-5-imidazol antibiotic. This is a special combination for the treatment of oral infections.

Ingredients in the drug formula

Active ingredients: Spiramycin base, Metronidazol.

Excipients: Lactose, Starch 1500, Povidon, Croscarmellose Sodium, Avicel, Magnesium stearate, Aerosil, Hydroxypropylmethyl cellulose 15cP, Hydroxypropylmethyl cellulose 6cP, Polyethylene glycol 6000, Talc, Titanium dioxide, Ponceau lake color.

How much does Dorogyne cost?

Dorogyne drug costs about 36,000 VND/box. However, prices may vary depending on time and other factors.

What are the uses of Dorogyne?

  •  Dorogyne is used to treat acute and chronic oral infections or recurrent conditions such as tooth abscess, inflammation, perimandibular cellulitis, periodontitis, gingivitis, periodontitis, stomatitis …
  • Dorogyne is used to prevent oral infections after surgery
  • In addition, the drug is also used as a prophylactic antibiotic before surgery and in patients with reduced body resistance.

Contraindications of Dorogyne

Dorogyne should not be used if the patient falls into one of the following cases:

  • Allergy to Imidazol or Spiramycin, Erythromycin or to any ingredient in the formulation
  • Target audience is children under 6 years old

How to use Dorogyne effectively?

How to use

Dorogyne is taken orally and should be taken with meals.

Dosage of Dorogyne

Adult

  • Dose: take 4-6 tablets/day, divided into 2-3 times a day.
  • Note, in severe cases, can be up to 8 tablets / day.

Children

  • From 6 to 9 years old: take 2 tablets / day, divided into 2 times / day
  • From 10 to 15 years old: take a dose of 3 tablets / day, divided into 3 times / day

Dorogyne side effects

  • The drug causes digestive disorders such as stomach pain, nausea, vomiting, diarrhea
  • Hives
  • Appearance of a metallic taste in the mouth, glossitis, stomatitis, moderate leukopenia recovered immediately after stopping the drug
  • Dizziness, ataxia, paresthesia, sensory and motor polyneuropathy may also occur due to prolonged duration of treatment, although rarely.

Dorogyne may cause digestive upset

Interactions that occur when taking Dorogyne

  • Disulfiram
  • Anticoagulants (warfarin)
  • Non-depolarizing cura derivative (Vecuronium)
  • Fluoro-uracil
  • Lithium

Precautions while using Dorogyne

  • If ataxia, dizziness, and mental disturbances occur, the drug should be discontinued
  • Note that in patients with CNS and peripheral neuropathy, stable or progressive, the psychiatric risk may be exacerbated.
  • Avoid alcohol (Antabuse effect)
  • In case of leukopenia, decide whether to continue treatment based on the degree of infection
  • Use caution when using Spiramycin for people with liver dysfunction because the drug can be toxic to the liver
  • In addition, the use of high doses of Dorogyne for the treatment of anaerobic infections and for the treatment of amoeba and Giardia can cause blood organ disorders and neurological diseases.

Dorogyne: composition, use, price and effective use

Using the drug along with alcohol can cause the Antabuse effect

Special Uses

Driving and operating machinery

The drug rarely causes central nervous system effects such as dizziness, so it can be used in this subject. However, it is also necessary to be cautious, if during use, there are symptoms above, you should stop taking the drug to ensure safety.

Women who are pregnant or breastfeeding

Dorogyne crosses the placenta, so it should be avoided during the first trimester of pregnancy. In addition, metronidazol and spiramycin are excreted in human milk, therefore, their use should be avoided during lactation.

Treatment of Dorogyne overdose

Metronidazole overdose 

Metronidazole orally as a single dose up to 15 g has been reported.

Symptoms of Overdose

  •  Nausea
  • Vomit
  • Loss of air conditioner
  • Neurotoxic effects including convulsions and peripheral neuritis have been reported

To solve

  • There is no specific antidote yet
  • Focus on symptomatic treatment and support

Spiramycin overdose

Symptoms of overdose: nausea, vomiting , diarrhea, etc.

To solve

  • Immediately notify your doctor about an overdose of Spiramycin
  • Focus on treating symptoms

What to do when you miss a dose of Dorogyne

  • Use as soon as you remember that you have missed a dose.
  • If the missed dose is close to the next dose, skip the missed dose and follow the dosing schedule.
  • Do not take a double dose to make up for the missed dose.

Methods of preservation

  • Keep Dorogyne out of the reach of children and pets.
  • Store the medicine in a cool, dry place. Avoid exposure to direct light or keep the medicine in humid places.
  • The best storage temperature is below 30 ºC.

Above is the information on the use of Dorogyne . Call your doctor right away if you have any unusual symptoms so that you can get timely treatment and support!