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Everything you need to know about Glotadol (paracetamol)

What is Glotadol (paracetamol)? How does the drug work to be able to provide such a therapeutic effect? What should be kept in mind while taking the drug? Let's learn more about this with SignsSymptomsList!

Name of active ingredient: paracetamol.

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1. What is Glotadol (paracetamol)?

Paracetamol is also known as acetaminophen or N-acetyl-p-aminophenol.

This is an effective pain reliever - antipyretic that can replace aspirin. However, the difference with aspirin is that paracetamol is not effective in treating inflammation.

Talking about the main role of paracetamol, the drug helps to lower body temperature in febrile patients, but rarely lowers body temperature in normal people. The drug works by acting on the hypothalamus causing hypothermia, increasing thermogenesis due to vasodilation and increasing peripheral blood flow.

2. Indications of the drug Glotadol

Everything you need to know about Glotadol (paracetamol)

Glotadol (paracetamol)

It is widely used in the treatment of mild to moderate pain and fever.

3. Cases where Glotadol should not be used 

  • Allergy to paracetamol or to any of the other ingredients in the medicine.
  • Do not use in patients with advanced liver disease or severe hepatic impairment.

4. Instructions for taking Glotadol 

4.1. How to use

  • To be taken orally with water
  • The drug can be taken on an empty or full stomach because food does not affect the absorption of the drug.

4.2. Dosage

Subjects > 12 years old

  • Use 500-1000mg/time
  • Only drink once every 4-6 hours
  • Calculate the total dose of the drug and be careful not to use more than 4000mg/day

Children from 6 to 12 years old

  • Use the drug at a dose of 250 - 500mg / time
  • Give the child a drink every 4-6 hours
  • Children in this group should not use more than 2000mg/day

5. Glotadol side effects

  • Nausea, vomiting
  • Hypersensitivity reactions.
  • Effects on kidneys, nephrotoxicity when abused for a long time.
  • Appearance of skin rash (erythema, urticaria) and other allergic reactions. If fever and vesicles appear around the natural cavities, StevensJohnson syndrome should be suspected, the drug must be stopped immediately.
  • Hematopoietic system disorders such as causing neutropenia, pancytopenia, leukopenia), anemia

You should be aware of the rare event if a serious skin reaction such as Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome, acute generalized pustulosis occurs, is rare, but possible. cause death must stop taking the drug and see a doctor immediately for timely treatment.

6. What drugs should Glotadol avoid?

Everything you need to know about Glotadol (paracetamol)

  • Alcohol
  • Medicines containing the active ingredient paracetamol
  • Colestyramine
  • Drugs that affect liver enzymes (such as isoniazid), phenytoin, carbamazepine, etc.
  • Phenothiazines
  • Ethinylestradiol
  • Probenecid
  • Activated carbons
  • Anticoagulants

7. Precautions when taking Glotadol (paracetamol)

  • At therapeutic doses paracetamol is relatively non-toxic. However, overdose is the main cause of acute liver failure. And the cause is often caused by taking many products containing paracetamol.
  • It is necessary to stop taking the drug and seek medical attention immediately if a rash or other skin manifestations or hypersensitivity reactions occur during treatment. 
  • Use with caution in people with liver failure, kidney failure, alcoholics, chronic malnutrition or dehydration.
  • Caution must be exercised in patients with pre-existing anemia, as cyanosis may not be evident, despite dangerously high concentrations of methemoglobin in the blood.
  • Alcohol should be limited or avoided because heavy drinking can increase the hepatotoxicity of paracetamol.

8. Special subjects when taking drugs

8.1. Pregnant

Everything you need to know about Glotadol (paracetamol)

There are no adequate studies evaluating the safety of paracetamol during pregnancy in relation to its potential adverse effects on fetal development.

Therefore, it is necessary to carefully consider, if the benefit to the mother outweighs the risk that the drug may harm the fetus, then decide to take the drug.

8.2. Breastfeeding Women

Some studies have shown that when used in lactating women, there are no harmful effects on the baby.

9. Treatment of an overdose of Glotadol

9.1. Symptoms of Overdose

This condition can be caused by a single toxic dose, by repeated large doses of paracetamol (eg, 7.5 – 10 g per day, for 1 – 2 days), or by long-term administration.

This can cause:

  • Hepatic necrosis (the most serious acute toxic effect from overdose and possibly death)
  • Nausea, vomiting, and abdominal pain usually occur within 2 to 3 hours.
  • Methemoglobinemia causes cyanosis of the skin, mucous membranes and nails.
  • In severe poisoning, there may be initial CNS stimulation, agitation, and delirium. Next may be central nervous system depression: stupor, hypothermia, fatigue, rapid, shallow breathing; rapid, weak, irregular pulse, low blood pressure and circulatory failure.
  • Shock can occur if multiple vasodilation. Fatal suffocation seizures, often coma, occur before sudden death or after several days of coma.

9.2. How to deal with it?

When intoxication is severe, it is important to start with active supportive treatment. The patient should undergo gastric lavage in all cases, preferably within 4 hours of ingestion. In addition, the antidote must be taken immediately, as soon as possible if less than 36 hours have passed since paracetamol.

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10. What to do when you miss a dose of Glotadol 

  • If you miss a dose, take it as soon as you remember
  • Do not take a double dose to make up for a missed dose
  • If it is almost time for your next dose, skip the missed dose and take it at your usual schedule.

11. How to store medicine

  • Keep the medicine out of the reach of children and pets.
  • Avoid leaving the medicine in a humid place such as a bathroom. Avoid direct light.
  • Store in a dry place at 15-30°C. 
  • Do not use expired drugs and know how to handle these drugs before releasing them into the environment.

Above is the information to note when using Glotadol. Call your doctor if you have any unusual symptoms for timely support!

Pharmacist Nguyen Ngoc Cam Tien