Things to note when taking Lornoxicam

What is Lornoxicam? In what cases is Lornoxicam used? What should be noted about possible side effects while taking the drug? Let's learn more about Lornoxicam with SignsSymptomsList in the article analyzed below!

Active ingredients : Lornoxicam
Drugs with similar active ingredients: Lornoxicam, Livorax, 

content

• 1. What is Lornoxicam?
• 2. Indications of the drug Lornoxicam
• 3. Lornoxicam should not be used if
• 4. How to use Lornoxicam effectively?
• 5. Side effects
• 6. Interaction occurs when taking Lornoxicam
• 7. Notes when taking Lornoxicam
• 8. Special Uses
• 9. Treatment of Lornoxicam overdose
• 10. What to do when you miss a dose of Lornoxicam
• 11. How to preserve

1. What is Lornoxicam?

Ingredients in the drug formula

Active

• Lornoxicam……………………………………………………..8 mg 

Excipients

• Lactose monohydrate
• Wheat starch
• Microcrystalline Cellulose 101
• Povidon K30
• Sodium starch glycolate, Magnesium stearate
• HPMC 615, HPMC 606, PEG 6000
• Titanium Dioxide, Talc
• Candurin silver sheen, Quinolin yellow lake 

Lornoxicam (chlortenoxicam) is a new non-steroidal anti-inflammatory drug (NSAID) of the oxicam group. The drug has analgesic, anti-inflammatory and antipyretic effects.

Lornoxicam works by partially inhibiting prostaglandin synthesis (cyclooxygenase enzyme inhibitor).

See also:  What do you know about the pain reliever Cataflam (diclofenac)?

2. Indications of the drug Lornoxicam

• Lornoxicam is used for the short-term treatment of acute, mild to moderate pain.
• In addition, Lornoxicam also helps to treat the symptoms of pain caused by osteoarthritis and rheumatoid arthritis.

3. Lornoxicam should not be used if

• Allergy to Lornoxicam or to any of its ingredients.

• Subjects had a history of hypersensitivity reactions to other nonsteroidal anti-inflammatory drugs, including acetyl salicylic acid with symptoms such as
  + Bronchospasm
  + Rhinitis
  + Angioedema or urticaria.

• The patient has gastrointestinal bleeding, bleeding in the blood vessels in the brain.

• Bleeding and clotting disorders.

• Patients with peptic ulcer or who have had recurrent peptic ulcers

• Subjects had ever had severe hepatic impairment,  severe renal impairment (serum creatinine > 700 micromol/L).

• In addition, the drug should not be used in patients with thrombocytopenia or in patients with  severe heart failure .

• For patients who are elderly (> 65 years old) and weigh < 50="" kg="" and="" surgery="" surgery="">

• Caution in pregnant women in the last 3 months of pregnancy.

4. How to use Lornoxicam effectively?

4.1. How to use

• The medicine should be taken with plenty of water.
• Avoid taking with meals because it will reduce the absorption of the drug.

4.2. Dosage

4.2.1. Medicines for patients > 18 years old

In the treatment of acute pain

• Dosage: Take from 8 to 16 mg/day. In case of taking 16 mg/day, divided into 2 doses. Alternatively, treatment can also be started with 16 mg on the first day, then 8 mg/time x 2 times/day.
• After the first day, the total daily dose should preferably be ≤ 16 mg.

Treatment of rheumatoid arthritis and osteoarthritis:

• Dosage: from 8 to 16 mg/day.
• The maintenance dose should not exceed 16 mg/day.

4.2.2. Children and adolescents

• Because of this, information on the safety and effectiveness of the drug in this population has not been adequately studied.
• Lornoxicam is not recommended for use in children and adolescents <18="" age="">

4.2.3. Subject is the elderly

• No dose change is required for patients > 65 years of age, except in patients with renal or hepatic impairment.
• However, Lornoxicam should be used with caution in elderly patients because of a higher risk of gastrointestinal side effects compared with younger patients.

4.2.4. Patients with kidney failure

• In patients with mild to moderate renal impairment, the maximum dose is 12 mg/day in divided doses.

4.2.5. Patients with liver failure

• In patients with moderate hepatic impairment, the maximum dose is 12 mg/day in divided doses.
• The lowest possible dose should be used for the shortest duration of treatment to minimize the risk of experiencing side effects.

5. Side effects

• Headache, dizziness, drowsiness, altered appetite, increased sweating, weight loss, edema, allergies, asthenia, weight gain.
• Depression, insomnia.
• Conjunctivitis, visual disturbances.
• Abdominal pain, diarrhea, dyspepsia, nausea, vomiting, flatulence, dysphagia, constipation, gastritis, dry mouth, stomatitis
• Status of gastric reflux, peptic ulcer with or without bleeding, esophagitis, rectal bleeding, ..
• Anemia, ecchymosis, prolonged bleeding time, thrombocytopenia.
• Increase liver enzymes
• Leg cramps, muscle pain.
• Migraine headache, paresthesia, loss of mouth, tinnitus and tremor.
• Shortness of breath, symptoms of allergies in the upper respiratory tract.
• Allergic skin reactions such as dermatitis, flushing and itching, hair loss.
• Urinary disorders.
• Palpitations, tachycardia, changes in blood pressure.
• The drug has the potential to damage the kidneys. Therefore, it is necessary to monitor renal function while taking the drug
• The risk of cardiovascular thrombosis

6. Interaction occurs when taking Lornoxicam

• Food may decrease the absorption of Lornoxicam. Therefore, it should not be taken with a meal if a quick effect (analgesic) is required.
• Cimetidine
• Anticoagulants (warfarin)
• Phenprocoumon
• Heparin
• Sulphonylure
• Diuretics, ACE inhibitors, beta-channel blockers, Angiotensin II receptor antagonists: reduce the antihypertensive effect of these agents, antiplatelet agents, selective serotonin reuptake inhibitors (SSRIs) ), other NSAIDs
• Corticosteroids.
• Lithium
• Methotrexate
• Digoxin
• Quinolones
• Cyclosporin
• Tacrolimus
• Pemetrexed

7. Notes when taking Lornoxicam

• It should be used with caution in the following patients:
  + Patients with mild renal impairment (serum creatinine 150-300 μmol/l)
  + Moderate renal impairment (serum creatinine 300-700 μmol/l).
  Note that it should be discontinued if renal function is impaired during treatment.
• Renal function should be monitored in patients undergoing major surgery, heart failure, and patients treated with diuretics or in combination with drugs that may cause kidney damage.
• Patients with coagulopathy and liver failure should be closely monitored.
• Long-term treatment (> 3 months) requires monitoring of hematological tests (Hemoglobin), creatinine and liver enzymes.
• For patients > 65 years: renal and liver function should be monitored. In addition, caution should be exercised in elderly patients who have undergone surgery.
• Gastrointestinal bleeding, ulceration, or perforation, sometimes fatal, has been reported with all NSAIDs at any time point of treatment without necessarily presenting with signs, warnings, or experience of a reaction. serious gastrointestinal side effects. 
• In the event that gastrointestinal bleeding or ulceration occurs in a patient receiving Lornoxicam, treatment must be discontinued.
• Closely monitor patients with mild to moderate hypertension and/or mild to moderate heart failure, and patients with diabetes mellitus.
• Of note, the combined use of NSAIDs and heparin in the setting of spinal or epidural anesthesia increases the risk of spinal or epidural hematoma.
• Particular caution should be exercised when administered to patients who have or have ever had bronchial asthma.

8. Special Uses

8.1. Driving and operating machinery

• The drug may cause dizziness and drowsiness.
• If patients experience these symptoms while taking this medicine, they should not drive or operate machinery.

8.2. Pregnant

• There are no adequate data on the use of Lornoxicam in pregnant women; animal studies have shown reproductive toxicity. Therefore, Lornoxicam should not be used during the first and second trimesters of pregnancy
• Prostaglandin synthesis inhibitors used during the third trimester of pregnancy can cause fetal cardiopulmonaryngeal toxicity (premature closure of the ductus arteriosus and pulmonary hypertension), impaired renal function that may progress to renal failure and thus decrease the amount of amniotic fluid.
• Of note, towards the end of pregnancy, drugs that inhibit prostaglandin synthesis can increase the bleeding time of the mother and fetus and inhibit uterine contractions, leading to delay or prolongation of the transition. Yes. Therefore, the use of Lornoxicam is contraindicated in the third trimester of pregnancy.

Refer to the article:  Is it safe to use drugs during pregnancy?

8.3. Breastfeeding Women

• There are insufficient data on the excretion of Lornoxicam in human milk.
• However, Lornoxicam was excreted in the milk of lactating rats at relatively high concentrations.
• Therefore, avoid taking Lornoxicam in lactating women.

9. Treatment of Lornoxicam overdose

• To date, no cases of overdose have been reported. 
• However, it is possible to predict the symptoms following overdose which could be
  + Nausea, vomiting
  + Dizziness
  + Visual disturbances
  + Severe ataxia including coma, convulsions, lesions liver, kidney and coagulopathy.
• Treatment should be discontinued in case of proven or suspected overdose.
• Note, there is still no specific antidote for Lornoxicam
• Lornoxicam cannot be removed by dialysis.
• Focus on treating and supporting symptoms for patients

10. What to do when you miss a dose of Lornoxicam

• Use as soon as you remember that you have missed a dose.
• If the missed dose is close to the next dose. Skip the missed dose and follow the dosing schedule.
• Do not take a double dose to make up for the missed dose.

11. How to preserve

• Keep Lornoxicam out of reach of children and pets.
• Store the medicine in a cool, dry place. Avoid exposure to direct light or store Lornoxicam in humid places.
• The best storage temperature is <>

Above is the information on the use of Lornoxicam. Call your doctor immediately if you have any unusual symptoms so that they can be treated and supported promptly!

Pharmacist Nguyen Ngoc Cam Tien