What disease does Diamicron ® (Gliclazide) treat?

Diamicron or Diamicron MR is one of the most familiar oral medications used to treat diabetes (diabetes) today. So how is this medicine used? Please refer to detailed information in the following SignsSymptomsList article.

Active ingredient name : Gliclazide.

Similar drugs : Gliclada, Myzith MR 60, Glumeron…

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• What diseases does Diamicron help treat?
• How should Diamicron MR be used effectively?
• Drug price of Diamicron MR 30mg Diamicron MR 60 mg
• Who should not take the diabetes drug Diamicron MR?
• Are there any special warnings when taking Diamicron?
• Is Diamicron MR harmful to pregnant, nursing or driving women?
• What precautions should be taken when using Diamicron with other drugs?
• Effects of drugs Diamicron MR 30mg and Diamicron MR 60mg
• How to deal with an overdose of diabetes medicine Diamicron?
• What should I do when I want to stop taking Diamicron MR 30mg and 60mg?
• How are Diamicron 60mg and 30mg drugs stored?

What diseases does Diamicron help treat?

Diamicron or Diamicron MR is used to treat type 2 diabetes (non-insulin dependent diabetes mellitus) in adults. Especially when diet, exercise and weight loss alone are not enough to control blood sugar.

The main dosage bar is Diamicron 30mg and Diamicron 60mg. Manufacturer: Servier (Vietnam).

Diamicron MR 30mg . pill box

How should Diamicron MR be used effectively?

The daily dose may vary from 30 to 120 mg, taken as a whole tablet at breakfast. The dose will be adjusted according to the individual's metabolic response (blood glucose level, HbA1c).

If you forget to take a dose, do not take a double dose and do not increase the dose at the next dose. Must remember to take the pill every day for better effect.

The recommended starting dose is 30mg/day.

• If blood glucose is effectively controlled: continue treatment at this dose level.
• If blood glucose is not controlled: increase dose to 60, 90 or 120 mg/day at next step of therapy.
• The maximum recommended daily dose is 120mg.

Combination therapy with other antidiabetic agents such as biguanides, alpha glucosidase inhibitors or insulin requires close medical supervision.

Drug price of Diamicron MR 30mg Diamicron MR 60 mg

Price of drug Diamicron MR 30mg: about 145,000 VND/box of 2 blisters x 15 tablets.

The price of the drug Diamicron MR 60mg: about 165,000 VND/box of 2 blisters x 15 tablets.

Diamicron MR 60mg pill box

Who should not take the diabetes drug Diamicron MR?

Diamicron is contraindicated when:

• Hypersensitivity to gliclazide or to any of the excipients, other sulfonylurea drugs, sulfonamides, etc.
• Type 1 diabetes
• Diabetic pre-coma or coma: diabetic ketoacidosis
• Severe kidney or liver failure (insulin recommended)
• Treatment with Miconazole
• Breastfeeding.

Are there any special warnings when taking Diamicron?

Hypoglycemia

Diamicron should only be taken with a regular and complete diet (breakfast included). Because the use of Diamicron MR can be associated with a high risk of hypoglycemia, which can be prolonged and severe enough to require hospitalization and continuous glucose loading for several days. You should ask your doctor about the risks and symptoms of low blood sugar, its treatment, and the factors that increase this risk. In addition, it is necessary to adhere to the diet, exercise regime and periodically control the blood sugar level.

>> Not only facing the worry of high blood sugar, people with diabetes also face the risk of hypoglycemia. Master the signs and treatment of excessive hypoglycemia to protect yourself!

Hypoglycemia may occur when taking Diamicron MR 30mg and Diamicron MR 60mg

Factors that increase the risk of hypoglycemia

• Refusal or inability to cooperate (elderly).
• Malnutrition, erratic eating, skipping meals, fasting or dieting, drinking alcohol.
• After prolonged or strenuous exercise without adequate energy compensation.
• Renal failure and liver failure.
• Overdose of Diamicron MR.
• Endocrine disorders : thyroid disorders, hypopituitarism and adrenal insufficiency .
• Concomitant use of certain other drugs.

Poor blood sugar control

Blood sugar control during diabetes treatment can be affected by: fever, trauma, infection, or surgical intervention. The effectiveness of oral drugs in glycemic control may be impaired over time due to advanced disease or impaired response to treatment. Dosage adjustment and dietary adherence should be considered.

Test

Measurement of hemoglobin glycate (or fasting venous blood glucose concentration) is recommended to assess blood glucose levels. In people with G6PD deficiency, it is necessary to be cautious or replace the drug in a different class with the diabetes drug Diamicron (because it can cause hemolytic anemia).

Is Diamicron MR harmful to pregnant, nursing or driving women?

Pregnant

Treatment of diabetes should be initiated before pregnancy to reduce the risk of birth defects associated with uncontrolled diabetes. In particular, insulin is the solution for treating gestational diabetes, not an oral drug, it is necessary to switch to insulin before pregnancy, or as soon as pregnancy is discovered.

Breastfeeding Women

It is not known whether the drug passes into breast milk. However, due to the risk of hypoglycemia in the newborn, the drug is contraindicated in nursing women.

Driving and operating machinery

Diamicron has not been found to affect the ability to drive and use machines. However, you need to be careful about hypoglycemia, especially in the early stages of treatment.

What precautions should be taken when using Diamicron with other drugs?

With drugs that can increase the risk of hypoglycemia

• Contraindicated in combination with Miconazole (systemic route, oral mucosal gel).
• Not recommended in combination with: Phenylbutazone (systemic route); alcohol or drugs containing alcohol.
• Careful combination with: Other antidiabetic agents (insulin, acarbose, metformin, thiazolidinedione, dipeptidyl peptidase-4 inhibitors, GLP-1 receptor antagonists); beta-channel blockers, fluconazole, ACE inhibitors (captopril, enalapril), H2-receptor antagonists, MAOIs, sulfonamides, clarithromycin, non-steroidal anti-inflammatory drugs.

With drugs that can increase blood sugar

• Not recommended combination: Danazol.
• Combination with caution: High dose chlorpromazine sedative; Glucocorticoids (systemic or topical route).
• Tetracosactrin; Ritodrine, Salbutamol, Terbutaline (intravenous route).

What drug should be considered when combining with any drug?

• Anticoagulant therapy (Warfarin): Diamicron increases the risk of anticoagulation when used concurrently.

Effects of drugs Diamicron MR 30mg and Diamicron MR 60mg

Common side effects

Hypoglycemia

With symptoms such as headache, intense hunger, nausea/vomiting, fatigue, anxiety, poor concentration, impaired cognition and slow reactions, weakness, visual and speech disturbances, aphasia , tremor, slight paralysis, sensory disturbances, dizziness, impotence, inability to self-regulate, delirium, convulsions, shallow breathing, bradycardia, loss of consciousness, possible coma and death.

Signs of parasympathetic conditioning

Sweating, cold skin, anxiety, rapid pulse, increased blood pressure, palpitations, angina, arrhythmia. If you have taken sugar and still get worse, you need to go to the emergency room or go to the hospital right away.

Digestive disorders

Abdominal pain, nausea, vomiting , indigestion, diarrhea, constipation. It can be prevented by taking Diamicron brand -name drug at breakfast.

Side effects are rarer

• Skin rash, pruritus, urticaria, angioedema, erythema, pre-existing skin rash, blistering.
• Anemia, leukopenia, thrombocytopenia, agranulocytosis.
• Increased liver enzymes, hepatitis.
• Transient visual disturbances.

How to deal with an overdose of diabetes medicine Diamicron?

An overdose of Diamicron can cause hypoglycemia. If you have:

• Mild symptoms of hypoglycaemia, without loss of consciousness or neurological signs: immediate glucose intake, dose adjustment, dietary modification. Control until the danger is gone.
• Severe hypoglycaemic reaction with coma, convulsions or other neurological disturbances: immediate hospitalization and emergency care is required. Strict control until the danger is gone.

Hypoglycaemic coma may occur with an overdose of Diamicron MR 30 mg or Diamicron MR 60 mg

What should I do when I want to stop taking Diamicron MR 30mg and 60mg?

The treatment of diabetes is usually lifelong, you must discuss with your doctor before stopping because it can cause high blood sugar and lead to diabetes complications. If you have any questions about using Diamicron, ask your doctor/pharmacist.

How are Diamicron 60mg and 30mg drugs stored?

Medicines must be kept out of reach of children. Do not use past the expiration date printed on the box and blister pack. Store the medicine at a temperature below 30°C. Do not dispose of drugs in sewage or household waste. Ask your pharmacist how to dispose of unused medicine, this will help protect the environment.

Diamicron or Diamicron MR is one of the oral drugs used to treat diabetes effectively. The use of the drug should be used after consulting a doctor, pharmacist. If you have signs of diabetes, immediately see a specialist in Endocrinology - Diabetes to get the most appropriate advice.