What do you know about Phenergan topical (promethazine)?

Phenergan (promethazine) is a very common drug used in cases of pruritus. Can all cases of itching be treated with medication? How to use it properly? Let's find out the necessary information about Phenergan with SignsSymptomsList.

Main active ingredient: promethazine.

Medicines containing similar ingredients: Pipolphen.

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• 1. What is Phenergan (promethazine)?
• 2. How to use Phenergan (promethazine) 
• 3. In case of not taking Phenergan (promethazine)
• 4. Be careful when using Phenergan 
• 5. Side effects when taking Phenergan (promethazine)
• 6. How to store Phenergan (promethazine)
• 7. For pregnant and lactating women?
• 8. Handling drug overdose 

1. What is Phenergan (promethazine)?

Phenergan (promethazine) is a synthetic antihistamine with local anesthetic properties. Promethazine is a phenothiazine derivative with strong antihistamine and sedative effects.

The drug has a competitive effect with histamine (an inflammatory mediator) for binding to its receptors on effector cells. This prevents the inflammatory response caused by histamine, but does not prevent the release of histamine. This is an older generation antihistamine, so it can cause central nervous system depression, manifesting as sedation, which is common when used in therapeutic doses for antihistamines.

Promethazine also has antiemetic, anticholinergic, anti motion sickness and local anesthetic effects. Phenergan contains promethazine, but in the form of a topical cream. The drug has both anti- allergic effect on the skin and is less absorbed into the blood, does not affect the central nervous system.

2. How to use Phenergan (promethazine) 

Phenergan topical (promethazine)

You need to wash and dry the area to be applied. Take an appropriate amount and apply a thin layer to the skin. Apply 3-4 times a day.

3. In case of not taking Phenergan (promethazine)

• Eczema .
• Children under 2 years old.
• Watery skin lesions
• Skin diseases with infection

4. Be careful when using Phenergan 

• Not recommended for use in children under 2 years of age as safety has not been established.
• Promethazine has a photosensitive effect. It is necessary to avoid sun exposure and UV exposure to the skin during treatment.
• For children with signs and symptoms of Reye's syndrome, Phenergan should be avoided. Due to the risk of extrapyramidal symptoms in these children, especially when high doses are used, the diagnosis is difficult.

5. Side effects when taking Phenergan (promethazine)

Depending on the location of each person, you may experience side effects when using the drug. The most common unwanted reactions of the drug are on the skin such as itching, sensitivity to sunlight ...

Tell your doctor or pharmacist any unwanted effects when using it. Also, to avoid possible interactions between more than one drug, inform your doctor or pharmacist of all other medications you are taking.

6. How to store Phenergan (promethazine)

Store the medicine at 25°C – 30°C, in a cool, dry place, away from direct light. Keep medicine out of reach of children

7. For pregnant and lactating women?

• Pregnant women

It should be cautiously avoided during the first trimester of pregnancy because there are insufficient data on its safety. For women in the second and third trimesters of pregnancy. Use only when needed, use in low doses. The infant's neurological and digestive functions should be monitored for some time.

• Breastfeeding Women

You can use Phenergan for this subject because it is a cream drug, so it is less absorbed into the body.

8. Handling drug overdose 

In case of overdose, consult a doctor immediately. The toxicity of the drug is mainly on the nervous system such as loss of synergy and hallucinations, apnea, etc.

The reference price at the pharmacy is about 13,000 VND/tube.

Phenergan is a drug commonly used for children, especially cases of itching caused by insect bites. However, the drug is contraindicated for children under 2 years of age. Itching can also have many causes. You need to see a dermatologist to get the correct diagnosis.

Pharmacist Ta Hoan Thien Quan