What do you know about the diabetes drug Galvus Met (metformin/vildagliptin)?

Galvus Met (metformin/vildagliptin) is used for which diseases? What should be paid attention to when taking the drug? Join SignsSymptomsList to learn about the carefully analyzed article below to know more about the role of Galvus Met!

Active ingredient names : vildagliptin and metformin hydrochloride.

Strength : there are 3 types of strength: 50 mg vildagliptin and 500 mg metformin hydrochloride; 50 mg of vildagliptin and 850 mg of metformin hydrochloride; 50 mg of vildagliptin and 1000 mg of metformin hydrochloride.

Manufacturer : Novartis Pharmaceuticals Australia Pty Ltd.

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• What is Galvus Met (metformin/vildagliptin)? 
• What are the uses of Galvus Met (metformin/vildagliptin)?
• Contraindications
• How much does Galvus Met (metformin/vildagliptin) cost? 
• Dosage of Galvus Met (metformin/vildagliptin) 
• How to take Galvus Met (metformin/vildagliptin)  
• Things to keep in mind when taking Galvus Met (metformin/vildagliptin)  
• Galvus Met (metformin/vildagliptin) side effects 
• Drug interactions  
• What to do in case of overdose? 
• Methods of preservation

What is Galvus Met (metformin/vildagliptin)? 

Galvus Met is a drug used to treat type 2 diabetes . Both active ingredients, vildagliptin and metformin, help control blood sugar levels.

• Vildagliptin: belongs to a new generation of antidiabetic drugs, improves insulin secretion by the pancreas dependent on blood glucose levels. 
• Metformin: works by helping the body use insulin better and does not cause excessive hypoglycemia. In addition, Metformin also exhibits beneficial effects on lipid metabolism (reducing total cholesterol, LDL-cholesterol and triglycerides) and preventing complications of diabetes.

The diabetes drug Galvus Met (metformin/vildagliptin)

What are the uses of Galvus Met (metformin/vildagliptin)?

• Treatment of type 2 diabetes mellitus: in adult patients who are unable to achieve complete glycemic control with maximally tolerated doses of metformin or have been treated with the combination of vildagliptin and metformin as separate tablets.
• In combination with a sulphonylurea (that is, triple combination therapy): as an adjunct to diet and exercise in adult patients partially controlled with metformin and a sulphonylurea.

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Contraindicated with objects: 

• Severe renal failure (GFR <30 ml="">
• Diabetic pre-coma.
• Acute metabolic acidosis (eg, lactic acidosis, diabetic ketoacidosis).

Acute cases have the potential to change kidney function, such as:

• Shock.
• Loss of water. 
• Severe infection.
• Use an iodinated contrast agent.

Acute or chronic diseases can cause tissue hypoxia, such as:

• Shock.
• Heart or respiratory failure.
• Recent myocardial infarction .
• Liver failure.
• Acute alcohol intoxication, alcoholism.
• Do not use the drug in children under 18 years of age.

Galvus Met (metformin/vildagliptin) is not for use by pregnant or breastfeeding women.

Galvus Met (metformin/vildagliptin) should not be used during pregnancy

How much does Galvus Met (metformin/vildagliptin) cost? 

• The price of Galvus Met 50/500mg can fluctuate depending on the time, the price ranges from 700,000 to 870,000 VND/box of 6 blisters x 10 tablets
• Galvus Met 50Mg/850Mg box of 6 blisters x 10 tablets priced at 10,202 VND/tablet 
• Galvus Met 50mg/1000mg Box of 6 blisters x 10 tablets costs about 605,000 VND/ Box

Prices may vary depending on the pharmacy and time

Dosage of Galvus Met (metformin/vildagliptin) 

The dose of Galvus Met (metformin/vildagliptin) depends on your medical condition and tolerability. However, you should not take more than 100 mg of vildagliptin in a day. Cases with dose differences such as:

Not well controlled with the maximum tolerated dose of metformin monotherapy

• The starting dose of Galvus Met can be 50 mg/500 mg or 50 mg/850 mg or 50 mg/1000 mg twice daily (total vildagliptin dose is 100 mg daily) depending on the dose of metformin used.

Dosage for other cases:

• Switching from concomitant use of vildagliptin and metformin as separate tablets
• Galvus Met should be started with the dose of vildagliptin and metformin already being used.
• Not well controlled in dual combination with metformin and sulphonylurea

Take Galvus Met 50 mg twice daily (total vildagliptin dose is 100 mg daily) and the dose of metformin is similar to that already used. When Galvus Met is used in combination with a sulphonylurea, a reduction in the dose of the sulphonylurea should be considered to reduce the risk of excessive hypoglycemia.

How to take Galvus Met (metformin/vildagliptin)  

Swallow the tablet whole with water. The drug should be taken with food to reduce the gastrointestinal side effects of metformin.

In particular, if you are on a diabetic weight control diet, continue to exercise and eat right even while taking Galvus Met.

Things to keep in mind when taking Galvus Met (metformin/vildagliptin)  

Avoid drinking alcohol while taking the drug.

Some special subjects need to be careful when using the drug 

Pregnant and lactating women:

• Galvus Met should not be used while pregnant or planning to become pregnant in the near future. Consult your doctor while you are breastfeeding.

Driving and operating machinery:

• Do not drive or operate machinery if you feel dizzy while taking the medicine.

Galvus Met (metformin/vildagliptin) side effects 

Possible drug effects are nausea, dizziness, diarrhea

Common side effects: nausea, vomiting, diarrhea, abdominal pain, loss of appetite, dizziness, headache, tremor, metallic taste. In addition, you may experience: joint pain, fatigue, constipation , swelling of the hands, ankles or feet.

Some very rare patients may have symptoms such as: sore throat, runny nose, fever; lactic acidosis (drowsiness or dizziness, severe nausea or vomiting, stomach pain, irregular heartbeat or deep, rapid breathing); skin redness, itching; vitamin B12 deficiency (pallor, fatigue, psychiatric symptoms such as confusion or memory disturbances).

When combined with a sulphonylurea, patients may experience problems such as: dizziness, tremor, weakness, excessive hypoglycemia, excessive sweating. You should stop taking Galvus Met and see your doctor right away if you experience the following side effects:

• Angioedema.
• Lactic acidosis. 
• Liver disease (hepatitis). 

Drug interactions  

Vildagliptin has no clinical evidence of drug interactions with other oral antidiabetic agents (glibenclamide, pioglitazone, metformin hydrochloride) and some drugs such as amlodipine , digoxin, ramipril, simvastatin, valsartan or warfarin after administration. in combination with vildagliptin. 

Metformin has interactions with drugs containing active ingredients such as furosemide, nifedipine, glyburide, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim or vancomycin...

Some drugs have a tendency to increase blood sugar such as thiazide diuretics, corticosteroids, phenothiazines, phenytoin, nicotinic acid, estrogens, oral contraceptives, calcium channel blockers and izoniazid. Blood glucose levels should be closely monitored and the dose of metformin should be adjusted when administering or discontinuing these agents. 

What to do in case of overdose? 

Tell your doctor or pharmacist right away if you overdose on Galvus Met (>50mg metformin or >400mg vildagliptin).

If you forget a dose of Galvus Met, take it as soon as you remember. Skip the missed dose if it is almost time for the next dose. Do not take extra medicine to make up the dose.

Methods of preservation

Keep out of reach of CHILDREN.

Store at room temperature (below 30oC).

Do not use the medicine after the expiry date (after the “EXP” date) or the last days of the expiration month.

The above information hopefully can help you better understand the uses, dosage and precautions when using Galvus Met (metformin/vildagliptin) diabetes medicine.